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Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders, or osteoporosis.
Indomethacin works by reducing hormones that cause inflammation and pain in the body. Indomethacin is used to treat pain or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis.
This drug is also used with other medications to treat a certain type of eye problem (open-angle glaucoma). Acetazolamide is a "water pill" (diuretic). It decreases the amount of fluid that can build up in the eye.
Carbonic Anhydrase inhibitors cause acidosis by preventing bicarb reabsorption. They cause hypokalemia by increasing the tubular flow, thereby maintaining a K+ excretion gradient and minimizing the ability to reabsorb it. ... Hyperkalemia is caused by the potassium-sparing diuretics.
Carbonic anhydrase inhibitors cause increased excretion of bicarbonate with accompanying sodium, potassium and water, resulting in an increased flow of alkaline urine. They inhibit transport of bicarbonate into the interstitium from the proximal convoluted tubule.
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