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Drug interactions. The concurrent use of mesalamine with azathioprine or 6-mercaptopurine may increase the risk for blood disorders. The use of mesalamine with known nephrotoxic agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of nephrotoxicity.
Contraindications. Before using Canasa, tell your doctor if you have a history of allergic reaction to the medicine sulfasalazine (Azulfidine), have liver problems, have kidney problems, have ever had inflammation of the sac around your heart (pericarditis). It is not advised to use this medicine if you are pregnant.
Directions. The recommended dosage of Canasa in adults is 1000 mg administered rectally once daily at bedtime for 3 to 6 weeks depending on symptoms and sigmoidoscopic findings. If you are using a lower strength take this medication 1 to 3 times daily. This medication works best if you have a bowel movement before using it. Wash your hands before and after using the medication. Unwrap the suppository right before using. Try to handle it as little as possible because heat from your fingers may cause it to melt. Lie down on your left side with right knee bent. Gently insert the suppository, pointed end first, into the rectum with your finger. Use a small amount of lubricating gel on the tip of the suppository if desired. Remain lying down for a few minutes. Try to avoid having a bowel movement for 1 to 3 hours, keeping the suppository in place so the medicine can work.
Storage. Store below 25В°C (77В°F), may be refrigerated. Keep away from direct heat, light or humidity. Canasa suppositories will cause staining of direct contact surfaces, including but not limited to fabrics, flooring, painted surfaces, marble, granite, vinyl, and enamel. Keep CANASA away from these surfaces to prevent staining.
Precautions. This medication is similar to aspirin. Children and teenagers should not take aspirin or aspirin-related medications (such as salicylates) if they have chickenpox, flu, or any undiagnosed illness, or if they have just been given a live virus vaccine (such as varicella vaccine), without first consulting a doctor about Reye's syndrome, a rare but serious illness. Mesalamine may elevate test results when measuring urinary normetanephrine by liquid chromatography with electrochemical detection, because of the similarity in the chromatograms of normetanephrine and mesalamine's main metabolite, N-acetylaminosalicylic acid.
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