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In general, the generic preparations are less expensive than the brand drugs. As a rough estimate, a 12-week course of generic ribavirin is in the range of $550 to $850. Accordingly, the ribavirin component of a 48-week treatment course costs approximately $1100 to $1700.
The treatment begins with pegylated interferon and ribavirin for the first four weeks, then Victrelis is added. The weekly cost of Victrelis is $1,100, according to Specialty Pharmacy News, meaning a 24-week treatment would cost approximately $22,000; a 48-week treatment would cost $48,400.
In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
Ribavirin is used with an interferon medication such as peginterferon alfa-2a [Pegasys] or peginterferon alpha-2b [PEG-Intron]) to treat hepatitis C in people who have not been treated with an interferon before. Ribavirin is in a class of antiviral medications called nucleoside analogues.J
The wholesale acquisition cost (WAC) for sofosbuvir is $1,000 per 400 mg pill. Accordingly, the cost for the sofosbuvir component in a 12-week treatment course is $84,000 (and the total regimen cost is depends on the other medications used in combination with sofosbuvir).
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