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General information: Eplerenone is an aldosterone blocker. It works by blocking the hormone aldosterone, which lowers the amount of sodium and water the body retains. This helps to lower blood pressure to help prevent strokes, heart attacks, and kidney problems. It is also used to improve survival in patients who have certain heart problems (left ventricular systolic dysfunction and congestive heart failure) following a heart attack.
Storage: Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.
Drug interactions: The medications that may interact with Inspra are Lithium because the risk of its side effects may be increased by eplerenone; Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of eplerenone's side effects; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease eplerenone's effectiveness and increase the risk of high blood potassium levels and Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased.
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