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This medicine may cause dizziness, sleepiness, confusion or blurred vision and so may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance. This medicine may increase the effects of alcohol. There may be a small increased risk of suicidal thoughts and behaviour in people taking antiepileptic medicines such as pregabalin for any condition. For this reason, it is very important to seek medical advice if you, or someone else taking this medicine, experience any changes in mood, distressing thoughts, or feelings about suicide or self-harm at any point while taking this medicine. For more information speak to your doctor or pharmacist. This medicine may cause skin reactions. You should let your doctor know if you develop a rash, skin peeling, itching, or other unexplained skin reaction while taking this medicine. This medicine may sometimes cause allergic reactions, including angioedema. Consult your doctor immediately if you experience difficulty breathing or swallowing, or swelling of your face, lips, tongue or throat while taking this medicine. Some people have experienced withdrawal symptoms after stopping treatment (long-term or short-term) with this medicine. These have included insomnia, headache, nausea, diarrhoea, flu syndrome, nervousness, depression, pain, sweating and dizziness.
Lyrica capsules and oral solution both contain the active ingredient pregabalin, which is a medicine that is used for three different purposes - treating epilepsy, nerve pain and anxiety. The way in which pregabalin works is not fully understood. It is thought to work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters from these nerve cells. Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. Pregabalin is thought to reduce the release of neurotransmitters called glutamate, noradrenaline and substance P. Glutamate is a neurotransmitter that acts as a natural 'nerve-exciting' agent. It is released when electrical signals build up in nerve cells and subsequently excites more nerve cells. It is thought to play a key role in causing epileptic seizures. Reducing the release of glutamate from the nerve cells in the brain is thought to help stabilise the electrical activity in the brain and prevent epileptic fits. Pregabalin is used as an add-on treatment for adults whose epilepsy has not been well controlled by other anti-epileptic medicines. It is used to prevent partial seizures, and partial seizures that spread to secondary generalised seizures. Glutamate, substance P and noradrenaline are also involved in transmitting pain signals in the brain and nervous system. As pregabalin reduces the release of these neurotransmitters it can also be used to treat nerve pain occuring as a result of damage to or a disturbance in the function of nerves (neuropathic pain). It can be used for peripheral neuropathic pain, ie nerve pain in the hands, legs or feet, or central neuropathic pain, eg as a result of a spinal cord injury. Pregabalin can also used to treat generalised anxiety disorder, which is another condition thought to involve overactivity of glutamate, substance P and noradrenaline in the brain.
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